Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans
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چکیده
منابع مشابه
The insecticide avermectin b (la) activates a chloride channel in crayfish muscle membrane.
Effects of avermectin Bl a (AVM) have been tested on excised outside-out or inside-out patches of crayfish stomach muscle membrane. Continuous supervision of AVM (0.1-1 pmoll (-1)) to the outside-out patches induced openings of channels(22 pS) which were similar in conductance and kinetics to the chloride channels activated by glutamate, quisqualic acid, ibotenic acid and nicotinic agonists,whe...
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Caenorhabditis elegans spermatogenesis is especially suited for studies of nonrandom cytoplasmic segregation during cellular differentiation. Spermatocytes separate from an anuclear cytoplasmic core and undergo two sequential divisions. During the second division, intracellular organelles segregate specifically to spermatids as they bud from an anuclear residual body. We have applied patch-clam...
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OBJECTIVE: The free radical theory of aging suggests that cellular oxidative damage caused by free radicals is a leading cause of aging. In the present study, we examined the effects of a well-known anti-oxidant amino acid derivative, selenocysteine, in response to environmental stress and aging using Caenorhabditis elegans as a model system. METHOD: The response to oxidative stress induced b...
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Natural convection between vertical parallel plates occurs frequently in applications such as solar collectors and cooling of electronic instruments. The problem is a two dimensional developing buoyant flow. In this work, the two dimensional conservation equations are solved numerically for constant wall temperature and constant wall heat flux. The results for the local Nusselt number at the du...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1214318